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Chronic pain and neuropathy describe long-standing pain conditions caused by nerve injury or dysfunction (for example diabetic neuropathy, post-surgical neuropathy, complex regional pain syndrome). Patients experience persistent burning, numbness, tingling, sharp pain, or loss of function that often does not respond well to standard medicines. Preclinical and early clinical research suggests mesenchymal stem cells (MSCs) and related cell therapies may reduce inflammation, promote nerve repair, and relieve neuropathic pain — but protocols and results vary and most approaches remain experimental.

ClientNew MagazineDateMarch, 2022AuthorJim CarterShare

About the Disease

Chronic pain and neuropathy describe long-standing pain conditions caused by nerve injury or dysfunction (for example diabetic neuropathy, post-surgical neuropathy, complex regional pain syndrome). Patients experience persistent burning, numbness, tingling, sharp pain, or loss of function that often does not respond well to standard medicines. Preclinical and early clinical research suggests mesenchymal stem cells (MSCs) and related cell therapies may reduce inflammation, promote nerve repair, and relieve neuropathic pain — but protocols and results vary and most approaches remain experimental.

Institutes / Trials Offering Stem Cell Therapy for Chronic Pain & Neuropathy

  1. Cleveland Clinic (Center for Clinical Research)Cleveland, Ohio, USA
    • Awarded NIH funding to develop stem-cell-based approaches for complex regional pain syndrome (CRPS) and is running preclinical/early translational programs toward clinical use. Cleveland Clinic
  2. University of Miami Health / Sports Medicine & Regenerative MedicineMiami, Florida, USA
    • Offers regenerative medicine programs (bone-marrow and adipose-derived stem cells) for chronic musculoskeletal pain and neuropathic conditions as part of their research and clinical services. University of Miami Health
  3. Boca Pain & Regenerative InstituteBoca Raton, Florida, USA
    • Provides clinic-based stem cell treatments for chronic pain (spine, neuropathy) as part of regenerative pain programs — consult clinic for protocols and eligibility. Boca Pain Institute
  4. New England Stem Cell InstituteGlastonbury, Connecticut, USA
    • Offers regenerative treatments for chronic pain conditions using autologous cell preparations; consult site for program details and locations. newenglandstemcells.com
  5. Stem Cell Medical Center / Private Clinics (e.g., Antigua, Panama)International
    • Several private/regenerative clinics worldwide offer MSC or umbilical-cord derived treatments for neuropathy and chronic pain; many publish case series but vary in study rigor. Exercise caution and verify trial data and approvals. Stem Cell Medical Center+1
  6. Active Clinical Trials (various sites)
    • Multi-site clinical trials and registries are exploring MSCs and related cell products for neuropathic pain and other chronic pain conditions (search ClinicalTrials.gov for up-to-date trial listings). ClinicalTrials